SOLVED: Why are loss-of-function mutations frequently recessive when heterozygous with wild-type allele?The loss-of-function allele often produces a new phenotype that is different from wild type. The loss-of-function allele is often silenced and only the wild-type allele is expressed. The wild-type protein function is often sufficient to compensate for the reduced-function protein. The wild-type allele is often expressed at higher levels compared to the loss-of-function allele.

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