00:00Welcome to 2-Minute Neuroscience, where I simplistically explain neuroscience topics in 2 minutes or less.
00:04In this installment, I will discuss the reward system.
00:08The reward system refers to a group of structures that are activated whenever we experience something rewarding, like using an
00:14addictive drug.
00:15When exposed to a rewarding stimulus, the brain responds by increasing release of the neurotransmitter dopamine.
00:20Thus, structures that are considered part of the reward system are found along the major dopamine pathways in the brain.
00:24The pathway most often associated with reward is the mesolimbic dopamine pathway, which starts in an area of the brainstem
00:31called the ventral tegmental area, or VTA.
00:34The VTA is one of the principal dopamine-producing areas in the brain, and the mesolimbic dopamine pathway connects it
00:39with the nucleus accumbens,
00:40a nucleus found in a part of the brain that is strongly associated with motivation and reward, called the ventral
00:45striatum.
00:46When we use an addictive drug or experience something rewarding, dopamine neurons in the VTA are activated.
00:51These neurons project to the nucleus accumbens via the mesolimbic dopamine pathway, and their activation causes dopamine levels in the
00:57nucleus accumbens to rise.
00:59Another major dopamine pathway, the mesocortical pathway, also originates in the VTA, but travels to the cerebral cortex, specifically to
01:06the frontal lobes.
01:07It is also activated during rewarding experiences, and is considered part of the reward system.
01:13Because dopamine is released whenever we use an addictive drug, researchers initially thought dopamine must be the neurotransmitter that causes
01:19pleasure.
01:20More recent research, however, suggests that dopamine activity doesn't correlate exactly with pleasure.
01:25For example, dopamine neurons are activated before a reward is actually received, and thus before the pleasure is experienced.
01:31For this, and other reasons, it is now thought that dopamine has roles other than causing pleasure, such as assigning
01:37importance to environmental stimuli associated with rewards, and increasing reward seeking.
01:42Whatever the precise role of dopamine in reward is, the mesolimbic dopamine pathway is consistently activated during rewarding experiences, leading
01:49it to be considered the main structure of the reward system.
01:52Regardless, the actual network of brain structures involved in mediating reward is much larger and more complex than just this
01:58dopamine pathway, involving many other brain regions and neurotransmitters.