Apr 15, 2021 · Toxicity can last 1-2 hours. Prolonged CPR may be indicated. If cardiopulmonary bypass or ECMO are available, these are indicated for refractory LAST.

The symptoms of toxicity were frequently described as seizures or respiratory failure, but some cases also included accounts of adverse cardiac effects. Often lethal, local anesthetic …

Describe potential risk factors for the development of LAST in patients undergoing surgery. Recognize the neurologic and cardiac symptoms related to LAST that could potentially lead to …

LAST primarily affects the central nervous system and cardiovascular system, and may be fatal. This topic will discuss the pathologic pharmacology, mechanisms, and clinical presentation of …

Nov 4, 2020 · Local Anesthetic Systemic Toxicity (LAST) refers to the effects, signs, and symptoms that systemic absorption of local anesthetic (LA) has on the body.

LAST can be mitigated by targeting the modifiable risk factors, including the use of ultrasound for regional anesthetic techniques and restricting drug dosage. There have been significant …

Oct 3, 2022 · From minor symptoms to major cardiac or central nervous system effects, local anesthetic systemic toxicity (LAST) is an important consequence of which to be aware. …

Herein, we present the 2020 version of the ASRA LAST checklist (figure 1) and discuss the rationale for its redesign.

Local anesthetic systemic toxicity (LAST) is a rare but potentially devastating adverse event re- sulting from the uptake of local anesthetic (LA) in the central nervous system (CNS) and cardio …

Local anaesthetic systemic toxicity (LAST) is a life-threatening adverse event that can occur following administration of any type of LA, administered by any route, if a large amount …