FOXA1 is a member of the forkhead domain transcription factor family. The forkhead domain is essential for its DNA-binding function, and consists of three alpha helices, three beta strands, and two loops …

Jan 15, 2026 · FOXA1 (Forkhead Box A1) is a Protein Coding gene. Diseases associated with FOXA1 include Hereditary Breast Ovarian Cancer Syndrome and Prostate Cancer. Among its related …

Apr 11, 2024 · This article focuses on the molecular mechanisms and clinical relevance of FOXA1 and FOXA2 in steroid hormone-induced malignancies and highlights potential strategies for targeting …

Through direct interactions with the Androgen Receptor (AR), FOXA1 helps to shape AR signaling that drives the growth and survival of normal prostate and prostate cancer cells. FOXA1 also possesses …

Oct 15, 2024 · Here, we report the chemical proteomic discovery of electrophilic compounds that stereoselectively and site-specifically bind the pioneer TF forkhead box protein A1 (FOXA1) at a …

Oncogenic activity of AR is critically enabled by chromatin-binding regulatory proteins, among which the pioneer transcription factor FOXA1 is particularly important. FOXA1 facilitates AR’s access to DNA …

Oct 15, 2024 · Today, FOXA1 is notoriously difficult to block with drugs—but that may soon change. Scripps Research scientists have identified a crucial binding site on FOXA1 that could pave the way …

Here, we show that FOXA1 upregulation induces genome-wide enhancer reprogramming and adopts a superenhancer mechanism to activate the master transcription factor HIF-2α and a prometastatic …

Oct 15, 2024 · Hormone-driven cancers, like those of the breast and prostate, often rely on a tricky-to-target protein called Forkhead box protein 1 (FOXA1).

Mar 28, 2026 · FOXA1 is a master suppressor of prostate cancer tumorigenesis and lineage plasticity. Here, the authors discover that FOXA1 loss in mice drives basal-squamous de-differentiation and …