Exon junction complex - Wikipedia
An exon junction complex (EJC) is a protein complex which forms on a pre-messenger RNA strand at the junction of two exons which have been joined together during RNA splicing. The EJC has major influences on translation, surveillance, localization of the spliced mRNA, and m …
The exon junction complex as a node of post-transcriptional
Dec 16, 2015 · The exon junction complex (EJC) is deposited onto mRNAs following splicing and adopts a unique structure, which can both stably bind to mRNAs and function as an anchor for diverse...
The Crystal Structure of the Exon Junction Complex Reveals How …
Aug 25, 2006 · The exon junction complex (EJC) plays a major role in posttranscriptional regulation of mRNA in metazoa. The EJC is deposited onto mRNA during splicing and is transported to the cytoplasm where it influences translation, surveillance, and localization of …
The Cellular EJC Interactome Reveals Higher Order mRNP Structure …
The EJC interactome and a new view of mRNP structure: Solid black line: exonic RNA; Dashed black line: a generic intron; Color ovals: proteins enriched more >10-fold in the EJC proteome listed in descending order of stoichiometry. Black ovals: undetected proteins known to bind to mRNA ends; Green spheres: bridging protein-protein interactions.
Biochemical analysis of the EJC reveals two new factors and a …
A central question regarding EJC structure is how it assembles and remains so tightly bound to mRNA in a sequence-independent fashion. Recently, we demonstrated that eIF4AIII interacts directly with mRNA at the position of the EJC in a splicing-dependent manner (Shibuya et …
The crystal structure of the exon junction complex reveals how it ...
Aug 25, 2006 · The exon junction complex (EJC) plays a major role in posttranscriptional regulation of mRNA in metazoa. The EJC is deposited onto mRNA during splicing and is transported to the cytoplasm where it influences translation, surveillance, and localization of …
Structure of the Exon Junction Core Complex with a Trapped ... - Science
Sep 29, 2006 · In higher eukaryotes, a multiprotein exon junction complex is deposited on spliced messenger RNAs. The complex is organized around a stable core, which serves as a binding platform for numerous factors that influence messenger RNA function.
The Exon Junction Complex Undergoes a Compositional Switch …
Nov 27, 2018 · The exon junction complex (EJC) deposited upstream of mRNA exon junctions shapes structure, composition, and fate of spliced mRNA ribonucleoprotein particles (mRNPs). To achieve this, the EJC core nucleates assembly of a dynamic shell of peripheral proteins that function in diverse post-transcriptional processes.
The exon junction complex (EJC) plays a major role in posttranscriptional regulation of mRNA in metazoa. The EJC is deposited onto mRNA during splicing and is transported to the cyto-plasm where it influences translation, surveil-lance, and localization of the spliced mRNA.
3EX7: The crystal structure of EJC in its transition state - RCSB PDB
Oct 16, 2008 · The exon junction complex (EJC) is deposited onto spliced mRNAs and is involved in many aspects of mRNA function. We have recently reconstituted and solved the crystal structure of the EJC core made of MAGOH, Y14, the most conserved portion of MLN51, and the DEAD-box ATPase eIF4AIII bound to RNA in the presence of an ATP analog.