Jan 16, 2024 · Atypical lobular hyperplasia (ALH) is a clonal proliferation of discohesive epithelial cells arising in terminal duct lobular units

Jun 2, 2022 · LCIS classic is a noninvasive, neoplastic proliferation of small, uniform, dyscohesive cells that originates in the terminal duct lobular unit and fills and distends most of the acini of the involved lobule

Apr 19, 2022 · Atypical ductal hyperplasia is an intraductal clonal epithelial cell proliferation with similar histologic features to (but insufficient involvement or volume for the diagnosis of) low grade ductal carcinoma in situ (DCIS)

Oct 3, 2023 · E-cadherin is a transmembrane protein involved in cellular adhesion and polarity maintenance

Stains - p120 cateninMembranous p120 catenin staining pattern is seen in many normal epithelial and nonepithelial tissues (Am J Surg Pathol 2007;31:427, Arch Pathol Lab Med 2014;138:1629, Histochem Cell Biol 2000;114:147) Normal breast epithelium and in situ / invasive ductal carcinomas show membranous p120 catenin expression (Histopathology 2016;68:57) Diffuse …

May 14, 2024 · Answer A is incorrect because atypical lobular hyperplasia (ALH) shows similar cytologic features to florid LCIS; however, criteria for ALH include either type A or type B cells that distend 50% or more acini within a lobule but not uniformly present throughout the entire terminal duct lobular unit (TDLU) or involves all acini in a TDLU but ...

Aug 18, 2020 · Stroma tends to be more cellular in early lesions and more collagenized and sclerotic with abundant elastin in older lesions Atypical hyperplasia (ADH, ALH) observed in 21 - 51% (Breast Cancer Res Treat 2008;107:371, Cancer 2003;97:345) In situ or invasive carcinoma may arise within or in association with radial scar / complex sclerosing lesions

Jun 11, 2021 · Nonneoplastic alteration characterized by spherules of basement membrane material surrounded by myoepithelial cells

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Oct 3, 2023 · Pleomorphic lobular carcinoma in situ (PLCIS) is a morphologic subtype of lobular carcinoma in situ (LCIS) composed of a noninvasive neoplastic proliferation of large dyscohesive cells with marked nuclear pleomorphism, > 4 times the size of a lymphocyte