Jul 20, 2018 · Understanding the molecular mechanisms controlling mitochondrial dynamics is crucial to decipher how mitochondrial shape meets the function and to increase the knowledge on the molecular basis of diseases associated with morphology defects.

Sep 6, 2023 · Herein, we review the mechanism of mitochondrial dynamics, and its impacts on cellular function. We also delve into the changes that occur in mitochondrial dynamics during health and...

Mitochondria are highly dynamic organelles undergoing coordinated cycles of fission and fusion, referred as ‘mitochondrial dynamics’, in order to maintain their shape, distribution and size. Their transient and rapid morphological adaptations are ...

Oct 17, 2024 · Here, we discuss recent structural insights into the assembly and mechanism of action of the core mitochondrial dynamics proteins, such as the dynamin-related protein 1 (DRP1) that controls...

Feb 18, 2020 · Here, we discuss mitochondrial membrane dynamics and their regulation and describe how bioenergetics and cellular signalling are linked to these dynamic changes of mitochondrial morphology.

Mechanism and regulation of mitochondrial dynamics. Mitochondrial fusion (upper left panel) is mediated by large dynamin-related GTPase proteins Mfn1, Mfn2, and OPA1. Mitochondrial outer membrane (MOM) fusion is mediated by Mfn1 and Mfn2, whereas mitochondrial inner membrane (MIM) fusion is mediated by OPA1.

Mitochondrial Dynamics refers to the observation that mitochondria within the individual cell go through fusion and fission events. Visually, this results in a morphological spectrum with contrasting degrees of elongation and fragmentation.

Mar 7, 2023 · The locution “mitochondrial dynamics” collectively describes the ability of mitochondria to (1) be transported along the cytoskeleton, (2) interact with other subcellular structures, and (3) shape their IMM and OMM through fusion and fission events.

Mar 16, 2023 · Here, we review the basic tenets and molecular mechanisms of mitochondrial morphology and ultrastructure, describing how they can coordinately define mitochondrial function.

Mar 14, 2025 · Explore how mitochondrial dynamics influence cellular energy, disease development, and overall health through the balance of fission, fusion, and regulation.