Delve into the kinase inhibitors' diverse landscape, from cancer breakthroughs to autoimmune disease innovations.

However, ongoing clinical trials first focused on cGvHD, which might be due to the importance of Syk in BCR downstream signaling, whereas it is not essential for TCR downstream events. In summary, the ...

ROME (AP) — Pope Francis remained in stable condition and didn’t need any mechanical ventilation Sunday, the Vatican said. It was a sign that he had overcome the possible complications from a ...

The advance-decline ratio (ADR) is at 0.77, close to the pandemic-era low of 0.72. It has remained below 1 for three months, signaling market weakness. Q3FY25 corporate results show sluggish revenue ...

one titled "Biobehavioral Medicine and Health Outcomes Study Section" and another titled "Cellular Signaling and Regulatory Systems Study Section." With an annual budget of $47 billion ...

BCR-ABL kinase is the major oncogenic driver of chronic myeloid leukemia (CML). Tyrosine kinase inhibitors (TKIs), which are highly potent in targeting BCR-ABL, are currently used as first-line ...

Multiple steps are involved in chronic lymphocytic leukemia (CLL) pathophysiology, and various factors are related to the development the disease: cytogenetic aberrations, antigenic triggers activated ...

This manuscript addresses an important question and provides some clear instructions on the use of the λ chain locus. In particular, it highlights the role of Kidins220 in extending B cell survival so ...

Cell signaling – also sometimes referred to as signal transduction or transmembrane signaling – controls basic cellular activities via complex responses. Signaling pathways coordinate communication ...

The next step will be to determine, at a molecular level, the basis for the autonomous signaling produced by the IgE B cell receptor when it is not bound to a specific substance. It will then be ...