A specific protein controls mRNA transport in fungi and distinguishes important from unimportant binding sites in the transported mRNAs. Researchers from Würzburg and Düsseldorf have discovered this ...

Brain cells manufacture proteins in every corner, including their long branches. Neurons missing this ability cause severe neurological disorders like disability and epilepsy. The groups of Marino ...

Genetic expression, often leading to protein synthesis, requires a complex coordination of molecular machinery across several stages. A vital step in protein-coding gene expression is messenger RNA ...

Following stimulation, cruising transport granules arrive at synapses and unload their contents. The mRNA anchors to the neuronal spine and undergoes translation (3). With repeated stimulation, ...

Both UAP56 and URH49, which form essential complexes for mRNA export, evolved from a common ancestral gene. However, the distinct roles that these complexes play, as well as the structural differences ...

In a recent study published in PNAS, researchers presented a scalable lipid nanoparticle (LNP) production (SCALAR) platform to produce high-throughput lipid nanoparticles on one microfluidic chip and ...

Scientists from the University of Pennsylvania have developed an ideal “recipe” for ionizable lipids, which are essential components of lipid nanoparticles (LNPs), the molecules that underlie the ...

“These publications provide a major advancement to elucidate the mechanisms underlying mRNA distribution in brain cells,” Marino Zerial says. Cells produce vital proteins using mRNA as a blueprint and ...