Overcoming acquired treatment resistance is one of the major challenges in the fight against cancer. While combination therapies hold promise, their toxicity to healthy tissue remains a major hurdle.

A vast number of chemicals are registered for production and use around the world. But only a portion have been thoroughly evaluated for their toxicity due to time, cost, ethical concerns and ...

NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of ...

Well before a human receives the first dose of an experimental drug, it’s evaluated in an animal to test for toxicity. Monkeys are often chosen for their genetic similarities to humans, and safe ...

In recent months, the Food and Drug Administration and National Institutes of Health have announced new initiatives to reduce and replace animal testing in biomedical research. Central to these ...

Non-animal framework based on new approach methodologies (NAMs) for chemical hazard identification and risk assessment. The framework comprises three modules: (1) high-throughput screening to address ...

As a researcher, I still remember the discomfort I felt every time I had to sacrifice laboratory animals for an experiment. For decades, animals like mice, rats and pigs have been essential tools in ...

A social media post from the US Food and Drug Administration this week shows a big-eyed macaque staring out from behind bars. “Some drugs use 144 monkeys on average for preclinical testing,” the post ...