In the paper, Blanpied describes an unexpected aspect to this architecture that may explain why synapses are so efficient, but also susceptible to disruption during disease: at each synapse, key ...

He suspects that if adhesion molecules are not placed correctly at the synapse, synapse architecture will be disrupted, and neurotransmitters won't be able to do their jobs.

In the new study, the authors describe an unexpected aspect to this architecture that may explain why synapses are so efficient, but also susceptible to disruption during disease.