When and how the spliceosome assembles on its substrates in living yeast cells has been unclear. It is now evident that the 'when' is during transcription; the 'how' remains debatable. Current models ...

Making a movie at the molecular level? A new method of imaging molecule-sized machines as they do the complex work of cutting and pasting genetic information inside the nucleus is the subject of a ...

The initial primary transcripts synthesized by RNA polymerase II (RNAPII) in eukaryotic cells undergo a series of modifications before functional messenger RNAs (mRNAs) exit the nucleus to be ...

Like a film director cutting out extraneous footage to create a blockbuster, the cellular machine called the spliceosome snips out unwanted stretches of genetic material and joins the remaining pieces ...

Many cases of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are associated with the C9ORF72 gene, which is known to encode toxic molecules, dipeptide repeat proteins, that ...

Humans share a comparable number of protein-coding genes with the simple roundworm Caenorhabditis elegans, yet we are arguably more sophisticated organisms. This difference in complexity is thanks to ...

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome ...

video: In this movie, which plays 360-times faster than real time, white spots represent light emitted from single fluorescent spliceosome subunits as they interact with single RNA (ribonucleic acid) ...

A new imaging technique can be used to understand the workings of complex biomolecular processes at a more detailed level than previously possible. The technique marks biomolecules with organic dyes ...

In multicellular organisms, the earliest products of transcription, called pre-mRNAs, undergo a molecular makeover before shipping out to the cytoplasm, where the modified mRNAs spell out the recipe ...

video: In this movie, which plays 150-times faster than real time, white spots represent light emitted from single fluorescent spliceosome subunits as they interact with single RNA (ribonucleic acid) ...