Small-molecule antiviral drug targets ACE2 receptor to block coronaviruses from entering cells

The ongoing evolution of SARS-CoV-2, particularly the rapid emergence of the omicron variant and its sublineages, has ...
SpaceNews

Small molecule interactions were central to the origin of life

In an important new paper forthcoming in the June issue of The Quarterly Review of Biology, Robert Shapiro (New York University) argues against the widely held theory that the origin of life began ...
Nature

RNA–ligand interaction scoring via data perturbation and augmentation modeling

Despite recent advances in RNA-targeting drug discovery, the development of data-driven deep learning models remains challenging owing to limited validated RNA–small molecule interaction data and ...
BioWorld

Small-molecule CD40-CD40L interaction inhibitors show promise in islet transplantation mouse models

Scientists from the Miller School of Medicine at the University of Miami have reported their recent work to develop small-molecule inhibitors of the CD40-CD40L (CD154) costimulatory protein-protein ...
Nature

Munc13-4–STX7 inhibitors impair endosomal TLR activation and systemic inflammation

Endosomal function is essential for pattern recognition receptor signaling, through endosomal Toll-like receptor (TLR) sensing of nonself RNA and DNA. The specific interaction of the calcium sensor ...
Benzinga.com

STAT+: Using AI to design small molecule drugs is tough. Here are five companies trying to crack the code

Ian Quigley was employee #13 at AI drug company Recursion until 2021, when he quit and turned the basement of his Utah home into a lab to develop AI models for predicting which proteins small molecule ...