The DNA copy that is made, called complementary DNA (cDNA), is then applied to the microarray. The cDNA binds to complementary base pairs in each of the spots on the array, a process known as ...

Review Article Published: December 2002 Options available—from start to finish—for obtaining data from DNA microarrays II Andrew J. Holloway, Ryan K. van Laar, Richard W. Tothill & David D.L ...

Microarrays—high-throughput platforms for analyzing the gene expression and features of total genomic DNA, among other applications—are gaining in popularity as researchers discover ever more ...

- John Sterling, Editor-in-Chief of GEN, interviews Claude Gagne, Ph.D., Associate Professor of Life Sciences, New York Institute of Technology School of Health Professions, Behavioral, and Life ...

ABSTRACT: Aberrant gene expression is critical for tumor initiation and progression. However, we lack a comprehensive understanding of all genes that are aberrantly expressed in human cancer. Recently ...

In the August 14 Proceedings of the National Academy of Sciences, Murray et al. describe an approach to explore genome diversity and relatedness in the absence of complete sequence information (Proc ...

Furthermore, our electrostatic detection technique should render DNA and RNA microarrays sufficiently cost effective for broad world-health applications, as well as research." ...

Two of the critical issues that arise when examining DNA microarray data are (1) determination of which genes best discriminate among the different types of tissue, and (2) characterization of ...

The research community's rapid acceptance of microarrays notwithstanding, technical challenges remain. Biochip developers continue to grapple with these issues while upgrading their offerings and ...

A major obstacle in cytostatic treatment of tumors is the development of resistance to many different antineoplastic drugs, called MDR. Up to date, clinical tests for predicting therapy response are ...