One such mechanism involves a protein called p53. Often dubbed the "guardian of the genome," this protein plays a pivotal role in ensuring that your cells grow, divide and die in an orderly fashion.

No one really understands why activation of the tumor suppressor p53 sometimes leads to cell-cycle arrest and sometimes induces an apoptotic program. It has been proposed that post-translational ...

Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney ...

A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled "Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells.

View Full Profile. Learn about our Editorial Policies. Comparing wild-type mouse embryonic fibroblasts to cells lacking the cell cycle regulator p53, molecular biologist Gregory Hannon of Cold Spring ...

Xenografted tumors derived from p53-deficient cells were highly vascularized ... Michael Thomson et al. conclude that miRNA processing seems to be regulated at a step mediated by the enzyme ...

The miRNA differential expression profiles of serum ... that the protein processing in the endoplasmic reticulum pathway, P53 pathway, and mRNA surveillance signaling pathway significantly ...