Microglial activation is a determining factor that allows amyloid-beta accumulation to drive reactive astrogliosis, amplifying inflammatory responses in the brain. This was the conclusion of a study ...

A sequence of stress signals among specialized clean-up cells in the brain could at last reveal why some immune responses can cause significant nerve degeneration that results in the loss of memory, ...

Neuroinflammation has emerged as a pivotal area of study over recent decades, propelled by its critical involvement in both ...

Researchers found that FcγR signaling in microglia may drive neuron loss in Parkinson’s disease models. Blocking FcγR ...

Alzheimer's disease (AD) is a highly debilitating neurodegenerative disease characterized by the progressive loss of memory and decline of mental functions. Earlier research has uncovered some of the ...

TMEM97 regulates microglial activation and neuronal stress pathways linked to neuropathic pain and neuroinflammation in multiple sclerosis (MS). Pharmacological targeting of TMEM97 has shown ...

When microglia wind up with a belly full of lipid droplets, it’s a sign that the cells are rallying, perhaps in vain, to a neurodegenerative threat. But according to a study published July 10 in Cell ...

New research from scientists at Max Planck Institute for Biology of Ageing, Icahn School of Medicine at Mount Sinai, and their collaborators helps elucidate the neuroprotective role of microglia, the ...

In Alzheimer's disease—the leading cause of dementia—microglia, the brain's immune defenders, can act as both protectors and aggressors, shaping how the disease progresses. Subscribe to our newsletter ...