These findings suggest that reduced ATG-9 scramblase activity may facilitate lysosome biogenesis and repair by modulating the distribution of phospholipids between the inner and outer leaflets of ...

Dysfunctional mitochondria are a hallmark of T cell ageing and contribute to organismal ageing. This arises from the accumulation of reactive oxygen species (ROS), impaired mitoch ...

They noted an increase in TFEB-target genes that promote lysosomal biogenesis and autophagy, supporting a cytoprotective rather than an inflammatory role. Tan hopes these insights will support ...

The mechanistic confirmation that blarcamesine restores impaired autophagy through S1R/SIGMAR1 activation by acting upstream of amyloid and tau pathologies at the molecular level was previously ...