Several methods have been described recently that permit researchers to exert post-translational control over gene products. An intein-based method shows it is a strong contender in the field by ...

Protein splicing is a naturally occurring post‐translational process in which inteins, as self‐excising protein segments, precisely remove themselves from a host polypeptide and concomitantly ligate ...

It's the ugly duckling story of the molecular world. Intein, thought two decades ago to be nothing more than a molecular parasite or a harmless hitchhiker, is today an invaluable tool in the ...

Why do problems occur with a special variant of 'protein glues', the split inteins, that severely limit their use in producing proteins? A team has now answered this question. Proteins are the ...

Occasionally, there are research findings that aren’t especially exciting but provide a great opportunity to provide a glimpse into fascinating areas of science. This week, PNAS was kind enough to ...

Controlling protein function in mammalian cells could get a little easier. Researchers at Harvard University describe a way to turn on proteins with self-splicing protein domains called inteins.

The SCN1A gene is too large to fit into aconventional viral delivery systems. Scientists overcame this hurdle with a pioneering "split-intein" mechanism, which is like two separate trucks, delivering ...

Controlling protein function in mammalian cells could get a little easier. Researchers at Harvard University describe a way to turn on proteins with laboratory-evolved self-splicing protein domains ...

At the recently concluded ARVO meeting, Splicebio S.L. presented the first preclinical results on the company’s new candidate, SB-007, for the treatment of Stargardt disease, a rare genetic disease ...

Long-standing problem solved: Researchers discover that misfolding prevents efficient utilisation of so-called split inteins as ‘protein glue’ Proteins are the building blocks of life. They consist of ...

Proteins are the building blocks of life. They consist of folded peptide chains, which in turn are made up of a series of amino acids. From stabilising cell structure to catalysing chemical reactions, ...