Conditional genetics and single-embryo RNA-seq show that SETDB1 extinguishes the transient, retroelement-driven transcriptional programs of the totipotent two-cell state to facilitate the exit from ...

Study reveals that genomic nuclear speckle-associated domains (SPADs) are step-wise organized during mouse early embryogenesis, with key factors contribution in this process. Following mammalian ...

The creation of a woolly-mouse embryo marks a significant leap in the field of de-extinction, bringing us one step closer to reviving the iconic woolly mammoth. By combining advanced gene-editing ...

The earliest days after fertilization, once a sperm cell meets an egg, are shrouded in scientific mystery. The process of how a humble single cell becomes an organism fascinates scientists across ...