Letter Published: 28 June 2001 Cyclin-dependent kinases prevent DNA re-replication through multiple mechanisms Van Q. Nguyen, Carl Co & Joachim J. Li Nature 411, 1068–1073 (2001) Cite this article ...

Replication in eukaryotes initiates from discrete genomic regions according to a strict, often tissue-specific temporal programme. However, the locations of initiation events within initiation ...

Journal Reference: Franziska Bleichert, Michael R. Botchan, James M. Berger. Crystal structure of the eukaryotic origin recognition complex. Nature, 2015; 519 (7543): 321 DOI: 10.1038/nature14239 ...

A clearer understanding of the origin recognition complex (ORC) - a protein complex that directs DNA replication - through its crystal structure offers new insight into fundamental mechanisms of DNA ...