Nature

Structural basis for engagement by complement factor H of C3b on a self surface

The ~30 proteins of the complement system cooperate to make a vital contribution to innate immunity 1. The complement system is important for clearing immune complexes and cellular debris and for ...
Nature

Secretion of soluble complement inhibitors factor H and factor H-like protein (FHL-1) by ovarian tumour cells

Ovarian cancer is the 6th most common malignant neoplasm among women worldwide, accounting for 4.3% of all female malignancies (Parkin et al, 1993). Despite advances in surgical and chemotherapeutic ...
JSTOR Daily

Defining a protective epitope on factor H binding protein, a key meningococcal virulence factor and vaccine antigen

Mapping of epitopes recognized by functional monoclonal antibodies (mAbs) is essential for understanding the nature of immune responses and designing improved vaccines, therapeutics, and diagnostics.
Business Wire

Gemini Therapeutics Announces FDA Fast Track Designation Granted for GEM103 for the Treatment of Dry Age-Related Macular Degeneration (AMD) in Patients With Complement Factor H ...

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Gemini Therapeutics, a clinical stage precision medicine company developing innovative treatments for genetically defined age-related macular degeneration (AMD), ...