Restructuring a molecule without rebuilding it from scratch is an increasingly important goal in modern organic chemistry.

Enzymes are amazing catalysts. These proteins are made of nothing more than a handful of Earth-abundant elements, and they promote a vast array of reactions, convert chemical energy to physical motion ...

Scientists have long considered ketones (a fundamental chemical class) and esters (molecules formed when an acid reacts with an alcohol) to be locked treasure chests of possibilities. Ubiquitous as ...

Cyclic peptides often exhibit low membrane permeability that can be significantly improved via amide-to-ester substitutions, as demonstrated by researchers from Tokyo Institute of Technology (Tokyo ...

Oxidation of saturated C−H bonds is a key chemical reaction in synthetic chemistry and chemical industry. Nevertheless, the high bond dissociation energies (BDEs) and weak polarity of C(sp 3)−H bonds, ...

Ketones and esters (formed when an acid reacts with an alcohol) are ubiquitous as pharmaceutical intermediates and widely used for the synthesis of drug molecules. However, both share a critical ...

Restructuring a molecule without rebuilding it from scratch is an increasingly important goal in modern organic chemistry. Skeletal editing is an ...