between two inbred mouse strains (C3H and DBA/2). Traditional backcross breeding strategies were used to generate reciprocal congenic lines in which the DBA/2 allele of Chrna5 or Chrna7 has been ...

However, even when mutant mice are maintained correctly as a randomly bred colony or as a continually backcrossed congenic strain, there are potential confounds. Although studying a mutation on a ...

This committee, formed in 1939 to ensure that names for mouse genes and linkage groups are standardized worldwide, also determines genetic criteria for the establishment of inbred and congenic strains ...

"What makes this study particularly compelling is our use of a congenic mouse model, which allows us to attribute behavioral changes specifically to the fragile X mutation," explains Professor ...