Study identifies impaired ER-to-golgi ceramide transport as a key regulatory node underlying senescence-associated sphingolipid remodeling.

Ceramide buildup due to faulty transport triggers stress responses that lock cells into senescence, revealing a potential ...

When cells experience enough chronic stress, they can stop dividing permanently. In this state of cellular limbo, known as replicative ...

The NSL (non-specific lethal) complex regulates thousands of genes in fruit flies and mammals. Silencing the NSL genes leads to the death of the organism, which gave the complex its curious name.

Pinpointing the stressors that help trigger or accelerate replicative senescence has proven difficult. Now, in a study ...