Over the past decade, several features of the B-cell receptor (BCR) complex have emerged as major markers for prognostic classification of B-cell chronic lymphocytic leukemia (B-CLL). In ...

BCR-ABL forms a dimer and/or tetramer through the coiled-coil domain in the N terminus of BCR, which is thought to promote BCR-ABL activation and oncogenesis by facilitating transphosphorylation ...